Melatonin

master hormone of the sleep-wake cycle

BeginnerWell-EstablishedGenerally Safe

Administration

Oral

Also Known As

N-acetyl-5-methoxytryptamine

Find on Amazon

Overview

Melatonin is a hormone naturally produced by the pineal gland in the brain in response to darkness. It signals to the body that it is time to sleep, regulating the circadian rhythm. As a supplement, it is widely used to combat jet lag, shift work sleep disorder, and general insomnia. Recent research also highlights its role as a potent systemic antioxidant.

Safety & Considerations

May cause next-day grogginess or vivid dreams at high doses. Long-term daily use is debated, though no strong evidence shows it halts natural production.

Always consult a healthcare professional. This information is for educational purposes only.

Benefits

Decreases the time it takes to fall asleep
Resets the body's circadian rhythm
Alleviates symptoms of jet lag
Acts as a powerful cellular antioxidant
Supports eye health and neuroprotection

How It Works

Exogenous melatonin binds to MT1 and MT2 receptors in the brain, inhibiting the wakefulness-promoting signals of the suprachiasmatic nucleus. This lowers core body temperature and initiates the physiological cascade of sleep.

Common Uses

Jet lag recovery
Occasional insomnia
Shift work schedule changes
Antioxidant therapy (high dose)

Typical Protocol

0.3mg to 3mg taken 30-60 minutes before desired bedtime. Lower doses are often more effective for sleep architecture.

Dosing information is for research reference only.

Research Status

Well-Established

For educational purposes only. Not medical advice. Consult a healthcare professional before starting any supplement regimen.

Frequently Asked Questions About Melatonin

What is Melatonin used for?

Jet lag recovery. Occasional insomnia. Shift work schedule changes. Antioxidant therapy (high dose).

What is the typical Melatonin protocol?

0.3mg to 3mg taken 30-60 minutes before desired bedtime. Lower doses are often more effective for sleep architecture.

Is Melatonin safe?

Safety rating: Generally Safe. May cause next-day grogginess or vivid dreams at high doses. Long-term daily use is debated, though no strong evidence shows it halts natural production.

How does Melatonin work?

This information is for educational purposes only and should not be taken as medical advice. Always consult a qualified healthcare professional.